Shortly after the broadcast of the 12th and final episode of Trigun Stampede, the anime production team announced that production on a “final phase” of the series is in development. They did not specify the format of the “final phase,” but released a new key visual and final PV trailer.
Crunchyroll also confirmed that the new Trigun Stampede anime will stream on its service when it returns.
The production staff for Trigun Stampede includes Kenji Mutou (Hello World co-storyboarder) as director, along with Tatsurou Inomoto (One-Punch Man Season 2 scriptwriter), Shin Okashima (Skull-face Bookseller Honda-san), and Yoshihisa Ueda as series screenwriters and scriptwriters. Orange is handling the animation production for the series.
Other staff members include Kouji Tajima as concept designer and original character designer, Takehiko Okishi as story supervisor, Eiji Yamamori (Godzilla Singular Point kaiju designer) as creature designer, Eiji Inomoto (BEASTARS) as CG chief director, Yuuji Kaneko (Ranking of Kings) as art director, Satoshi Hashimoto (Bubble) as color designer, and Takashi Aoki and Ryuuta Koshida as compositing directors.
Koudai Watanabe (“STUDY ME” director and character designer), Tetsurou Moronuki (THE IDOLM@STER CINDERELLA GIRLS: Spin-off!, Psycho Pass 3: First Inspector action animation director), Takahiko Abiru (Vinland Saga), Akiko Satou (Kimi no Matsu Basho e), Takeshi Ninomiya (Fate/Grand Order Final Singularity – Grand Temple of Time Solomon animation director), and Yumihiko Amano are all contributing as character designers for the series.

Meanwhile, the voice cast includes Yoshitsugu Matsuoka as Vash the Stampede, Junya Ikeda as Millions Knives, Tomoyo Kurosawa as Young Vash, Yumiri Hanamori as Young Knives, and Maaya Sakamoto as Rem Saverem.
Yasuhirou Nightow’s original Trigun manga was serialized in Tokuma Shoten’s Monthly Shonen Captain magazine from April 1995 to January 1997. Three tankoubon volumes were released by Tokuma Shoten and two volumes by Shounengahousha. The series was followed by Trigun: Maximum, which was serialized in Young King Ours magazine from October 1997 to March 2007. 14 tankoubon volumes of that series were released in total.
The manga previously received a 26-episode anime series adaptation that aired in 1998 and an anime film titled Trigun: Badlands Rumble that was released in 2010. These were produced by Madhouse and directed by Satoshi Nishimura.

Crunchyroll is streaming the anime and describes the story as:
Vash the Stampede’s a joyful gunslinging pacifist, so why does he have a $$6 million bounty on his head? That’s what’s puzzling rookie reporter Meryl Stryfe and her jaded veteran partner when looking into the vigilante only to find someone who hates blood. But their investigation turns out to uncover something heinous—his evil twin brother, Millions Knives.